Ewing Sarcoma Family is a group of neoplasms with source on neuroectodermal primitive cells that have the potential to differentiate into various types of tumors including the Ewing sarcoma (ES), primitive neuroectodermal tumor (PNET), peripheral neuroepithelioma and Askin tumor. These three are very closely related and the main difference among them being the degree of cell dissemination. Ewing Sarcoma is the second most common bone tumor which can be seen in childhood and adolescence but can also be a soft tissue sarcoma. The bone tumor is usually seen in the pelvis or femur whereas the soft tissue Ewing Sarcoma is often seen in the buttock, thigh, and chest wall.
The symptoms of Ewing sarcoma include swelling or tenderness in the affected region, bone pain (especially night pain), unexplained weight loss and tiredness, persistent low fever. In children it is usually mistaken for sports injuries.